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Maintaining imprinting

Nature Geneticsvolume 25pages45 (2000) | Download Citation

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The imprinting of a large cluster of paternally expressed genes at the Prader-Willi syndrome locus is established by an imprinting centre in human and mouse. Deletions carried by a member of a rare family and by chimaeric mice demonstrate that the imprinting centre is additionally required for postzygotic maintenance of paternal identity.

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Affiliations

  1. Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA

    • Mellissa R W Mann
    •  & Marisa S Bartolomei
    • Mellissa R W Mann
    •  & Marisa S Bartolomei

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https://doi.org/10.1038/75575

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