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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Nature Geneticsvolume 15pages356362 (1997) | Download Citation

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Abstract

Deletions involving regions of chromosome 10 occur in the vast majority (>90%) of human glioblastoma multiformes. A region at chromosome 10q23–24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.

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Affiliations

  1. Department of Neuro-Oncology, The Brain Tumour Center, University of Texas, M.D. Anderson Cancer Center, 1515Holcombe Boulevard, Houston, Texas, 77030, USA

    • Peter A. Steck
    • , Mark A. Pershouse
    • , Samar A. Jasser
    • , W.K. Alfred Yung
    • , Huai Lin
    •  & Azra H. Ligon
  2. Department of Pathology, The Brain Tumour Center, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

    • Lauren A. Langford
  3. Myriad Genetics Inc., 390 Wakara Way, Salt Lake City, Utah, 84108, USA

    • Michelle L. Baumgard
    • , Thomas Hattier
    • , Thaylon Davis
    • , Cheryl Frye
    • , Rong Hu
    • , Bradley Swedlund
    • , David H.R. Teng
    •  & Sean V. Tavtigian

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https://doi.org/10.1038/ng0497-356

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