Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension

Abstract

The angiotensin converting enzyme (ACE) is a key component of the renin angiotensin system that contributes to the regulation of blood pressure (BP). Recent demonstration of linkage between the ACE locus and elevated BP in a rat model of hypertension has further emphasized ACE as a candidate gene in human hypertension1,2,3. We report the localization of the ACE gene on the genetic map of chromosome 17, and identify an extremely polymorphic marker at the human growth hormone (hGH) locus which shows no recombination with ACE. We have found no evidence to support linkage between the ACE locus and hypertension, which suggests that mutations at the ACE locus do not commonly contribute to the pathogenesis of hypertension in our test population.

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References

  1. 1

    Hilbert, P. et al. Nature 353, 521–529 (1991).

  2. 2

    Jacob, H.J. et al. Cell 67, 213–224 (1991).

  3. 3

    Kurtz, T., Nature 353, 499 (1991).

  4. 4

    Ward, R. Hypertension: Pathophysiology, Diagnosis and Management (eds Laragh, J.H. & Brenner, B.M.)81–100 (Raven, New York, 1990).

  5. 5

    MacGregor, G.A., Markandu, N.D., Roulston, J.E., Jones, J.C. & Morton, J.J. Nature 291, 329–331 (1981).

  6. 6

    Erdös, E. R. & Skidgel, R.A. Lab. Invest. 56, 346–348 (1987).

  7. 7

    Sassaho, P. et al. Am. J. Mod. 83, 227–235 (1987).

  8. 8

    Harrap, S.H., Van der Merwe, W.M., Griffin, S.A., Macpherson, F. & Lever, A.F. Hypertension 16, 603–614 (1990).

  9. 9

    Suarez, B.K. & Van Eerdewegh, P. Am. J. med. Genet. 18, 135–146 (1984).

  10. 10

    Blackwelder, W.C. & Elston, R.C., Genet. Epidemiol. 2, 85–97 (1985).

  11. 11

    Hyer, R.N. et al. Am. J. hum. Genet. 48, 243–257 (1991).

  12. 12

    Bishop, D.T. & Williamson, J.A. Am. J. hum. Genet. 46, 254–265 (1990).

  13. 13

    Mattel, M.G. et al. Cytogenet. Cell. Genet. 51, 1041 (1989).

  14. 14

    Nakamura, Y. et al. Genomics 2, 302–309 (1988).

  15. 15

    Rigat, B. et al. J. clin. Invest. 86, 1343–1346 (1990).

  16. 16

    Rigat, B., Hubert, C., Corvol, P. & Soubrier, F. Nucl. Acids Res. (in the press).

  17. 17

    Harper, M.E., Barrera-Saldana, H.A. & Saunders, F.G. Am. J. hum. Genet. 34, 227–234 (1982).

  18. 18

    Ptacek, L.J. et al. Am. J. hum. Genet. 49, 378–382 (1991).

  19. 19

    Chen, E.Y. et al. Genomics 4, 479–487 (1989).

  20. 20

    Polymeropoulos, M.H., Rath, D.S., Xiao, H. & Merril, C.R. Nucl. Acids Res. 19, 689 (1991).

  21. 21

    Lange, K. Ann. hum. Genet. 50, 283–290 (1986).

  22. 22

    Alhenc-Gelas, F., Richard, J., Courbon, D., Warnet, J.M. & Corvol, P. J. Lab. clin. Med. 117, 33–39 (1991).

  23. 23

    Bratusch-Marrain, P.R., Smith, D. & DeFronzo, R.A. J. din. Endocrinol. Metab. 55, 973–982 (1982).

  24. 24

    Ferrannini, E. et al. N. Engl. J. Med. 317, 350–357 (1987).

  25. 25

    Pollare, T., Lithell, H. & Berne, C. Metabolism 39, 167–174 (1990).

  26. 26

    Reaven, G.M. & Chang, H. Am. J. Hypertens. 4, 34–38 (1991).

  27. 27

    Goldstein, J.L. & Brown, M.S. Ann. Rev. Genet. 13, 259–289 (1979).

  28. 28

    Haseman, J.K. & Elston, R.C. Behav. Genet. 2, 3–19 (1972).

  29. 29

    McLellan, T., Jorde, L.B. & Skolnick, M.H. Am. J. Hum. Genet. 36, 836–857 (1984).

  30. 30

    Lander, E. & Botstein, D. Genetics 121, 185–199 (1989).

  31. 31

    Todd, J.A. et al. Nature 351, 542–547 (1991).

  32. 32

    Weinberger, M.H., Miller, J.Z., Luft, F.C., Grim, C.E. & Fineberg, N.S. Hypertension 8, II-127–134 (1986).

  33. 33

    Lifton, R.P., Hunt, S.C., Williams, R.R., Pouyssegur, J. & Lalouel, J.M. Hypertension 17, 8–14 (1991).

  34. 34

    Jeunemaitre, X. et al. Hum. Genet. 88, 301–306 (1992).

  35. 35

    Lifton, R.P. et al. Nature 355, 262–265 (1992).

  36. 36

    Williams, R.R. et al. Am. J. Public Health 78, 1283–1286 (1988).

  37. 37

    Williams, R.R. et al. J.A.M.A. 259, 3579–3586 (1988).

  38. 38

    Segal, K. et al. J. appl. Physiol 58, 1565–1571 (1985).

  39. 39

    Lathrop, G.M., Lalouel, J.M., Julier, C. & Ott, J., Pro. natn. Acad. Sci. U.S.A. 81, 3443–3446 (1984).

  40. 40

    Hodge, S.E., Epidemiol. 1, 109–122 (1984).

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