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Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

Nature Genetics volume 1, pages 50–55 (1992)Cite this article

Abstract

Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a λgt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and “cut repeats”. As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, and the Howard Hughes Medical Institute, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Ellis J. Neufeld, Patricia M-J. Lievens & Stuart H. Orkin

  2. Wells Research Center, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, 702 Barnhill Dr., Indianapolis, Indiana, 46202, USA

    David G. Skalnik

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  1. Ellis J. Neufeld
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  2. David G. Skalnik
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  3. Patricia M-J. Lievens
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  4. Stuart H. Orkin
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Neufeld, E., Skalnik, D., Lievens, PJ. et al. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat Genet 1, 50–55 (1992). https://doi.org/10.1038/ng0492-50

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