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DNMT3A mutations in acute myeloid leukemia

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

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Figure 1: Model of DNMT3A activity.

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Correspondence to Jonathan D Licht.

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Shah, M., Licht, J. DNMT3A mutations in acute myeloid leukemia. Nat Genet 43, 289–290 (2011). https://doi.org/10.1038/ng0411-289

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