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Next-generation association studies for complex traits

A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.

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Correspondence to Eleftheria Zeggini.

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Zeggini, E. Next-generation association studies for complex traits. Nat Genet 43, 287–288 (2011). https://doi.org/10.1038/ng0411-287

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