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Somatic and germline genetics at the JAK2 locus

Nature Genetics volume 41, pages 385–386 (2009)Cite this article

Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.

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Figure 1: Hypotheses for interactions between germline and somatic genetic change.

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  1. Peter J. Campbell is at the Wellcome Trust Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk,

    Peter J Campbell

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  1. Peter J Campbell
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Campbell, P. Somatic and germline genetics at the JAK2 locus. Nat Genet 41, 385–386 (2009). https://doi.org/10.1038/ng0409-385

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