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Somatic and germline genetics at the JAK2 locus

Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.

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Figure 1: Hypotheses for interactions between germline and somatic genetic change.

References

  1. Jones, A.V. et al. Nat. Genet. 41, 446–449 (2009).

    Article  CAS  Google Scholar 

  2. Olcaydu, D. et al. Nat. Genet. 41, 450–454 (2009).

    Article  CAS  Google Scholar 

  3. Kilpivaara, O. et al. Nat. Genet. 41, 455–459 (2009).

    Article  CAS  Google Scholar 

  4. Campbell, P.J. & Green, A.R. N. Engl. J. Med. 355, 2452–2466 (2006).

    Article  CAS  Google Scholar 

  5. Levine, R.L., Pardanani, A., Tefferi, A. & Gilliland, D.G. Nat. Rev. Cancer 7, 673–683 (2007).

    Article  CAS  Google Scholar 

  6. Scott, L.M. et al. N. Engl. J. Med. 356, 459–468 (2007).

    Article  CAS  Google Scholar 

  7. Pikman, Y. et al. PLoS Med. 3, e270 (2006).

    Article  Google Scholar 

  8. Bellanne-Chantelot, C. et al. Blood 108, 346–352 (2006).

    Article  CAS  Google Scholar 

  9. Landgren, O. et al. Blood 112, 2199–2204 (2008).

    Article  CAS  Google Scholar 

  10. Stratton, M.R. & Rahman, N. Nat. Genet. 40, 17–22 (2008).

    Article  CAS  Google Scholar 

  11. Barrett, J.C. et al. Nat. Genet. 40, 955–962 (2008).

    Article  CAS  Google Scholar 

  12. Catlin, S.N., Guttorp, P. & Abkowitz, J.L. Blood 106, 2688–2692 (2005).

    Article  CAS  Google Scholar 

  13. Campbell, P.J. et al. Proc. Natl. Acad. Sci. USA 105, 13081–13086 (2008).

    Article  CAS  Google Scholar 

  14. Xu, X. et al. Blood 109, 339–342 (2007).

    Article  CAS  Google Scholar 

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Campbell, P. Somatic and germline genetics at the JAK2 locus. Nat Genet 41, 385–386 (2009). https://doi.org/10.1038/ng0409-385

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