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Adding pathogens by genomic subtraction

Two studies report the application of high-throughput sequencing technologies to discover infectious agents associated with diseased human tissues. These findings herald a breakthrough in the field of pathogen discovery.

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Figure 1: Computational subtraction involves interrogation of diseased human tissue by sequencing.

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MacConaill, L., Meyerson, M. Adding pathogens by genomic subtraction. Nat Genet 40, 380–382 (2008). https://doi.org/10.1038/ng0408-380

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