Two studies report the application of high-throughput sequencing technologies to discover infectious agents associated with diseased human tissues. These findings herald a breakthrough in the field of pathogen discovery.
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References
Feng, H., Shuda, M., Chang, Y. & Moore, P.S. Science 319, 1096–1100 (2008).
Palacios, G. et al. N. Engl. J. Med. 358, 991–998 (2008).
Cox-Foster, D.L. et al. Science 318, 283–287 (2007).
Chang, Y. et al. Science 266, 1865–1869 (1994).
Relman, D.A. Science 284, 1308–1310 (1999).
Relman, D.A., Loutit, J.S., Schmidt, T.M., Falkow, S. & Tompkins, L.S. N. Engl. J. Med. 323, 1573–1580 (1990).
Relman, D.A., Schmidt, T.M., MacDermott, R.P. & Falkow, S. N. Engl. J. Med. 327, 293–301 (1992).
Rota, P.A. et al. Science 300, 1394–1399 (2003).
Urisman, A. et al. PLoS Pathog. 2, e25 (2006).
Wang, D. et al. Proc. Natl. Acad. Sci. USA 99, 15687–15692 (2002).
Wang, D. et al. PLoS Biol. 1, E2 (2003).
Weber, G., Shendure, J., Tanenbaum, D.M., Church, G.M. & Meyerson, M. Nat. Genet. 30, 141–142 (2002).
Xu, Y. et al. Genomics 81, 329–335 (2003).
Tengs, T. et al. Nucleic Acids Res. 32, e121 (2004).
Margulies, M. et al. Nature 437, 376–380 (2005).
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MacConaill, L., Meyerson, M. Adding pathogens by genomic subtraction. Nat Genet 40, 380–382 (2008). https://doi.org/10.1038/ng0408-380
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DOI: https://doi.org/10.1038/ng0408-380
