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How missing genes interact

Nature Genetics volume 39, pages 440–442 (2007)Cite this article

Epistasis is an interaction among genes that makes the phenotypic effect of an allele dependent on which alleles are present at other loci. Two new genomic studies find abundant epistasis in the yeast genome, with significant implications for the evolution of sex and for the inference of genetic pathways from genomic data.

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Figure 1: Two forms of epistasis.

Kim Caesar

References

  1. Avery, L.W. & Wasserman, S. Trends Genet. 8, 312–316 (1992).

    Article  CAS  Google Scholar 

  2. Wolf, J.B., Brodie, E.D. III & Wade, M.J. Epistasis and the Evolutionary Process (Oxford Univ. Press, New York, 2000).

    Google Scholar 

  3. Jasnos, L.K. & Korona, R. Nat. Genet. 39, 550–554 (2007).

    Article  CAS  Google Scholar 

  4. Kondrashov, A.S. Nature 336, 435–440 (1988).

    Article  CAS  Google Scholar 

  5. St. Onge, R.P. et al. Nat. Genet. 39, 199–206 (2007).

    Article  CAS  Google Scholar 

  6. Lynch, M. et al. Evolution Int. J. Org. Evolution 53, 645–663 (1999).

    Article  Google Scholar 

  7. Haag-Liautard, C. et al. Nature 445, 82–85 (2007).

    Article  CAS  Google Scholar 

  8. Keightley, P.D. & Eyre-Walker, A. Science 290, 331–333 (2000).

    Article  CAS  Google Scholar 

  9. Elena, S.F. & Lenski, R.E. Nature 390, 395–398 (1997).

    Article  CAS  Google Scholar 

  10. de Visser, J.A.G.M., Hoekstra, R.F. & van den Ende, H. Genetics 145, 815–819 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Otto, S.P. & Feldman, M.W. Theor. Popul. Biol. 51, 134–147 (1997).

    Article  CAS  Google Scholar 

  12. Azevedo, R.B.R. et al. Nature 440, 87–90 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Clifford Zeyl is at the Department of Biology, Wake Forest University, Winston-Salem, North Carolina 27109, USA. zeylcw@wfu.edu,

    Clifford Zeyl

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  1. Clifford Zeyl
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Zeyl, C. How missing genes interact. Nat Genet 39, 440–442 (2007). https://doi.org/10.1038/ng0407-440

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