Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The resequencing imperative

The possibility of deep population resequencing of genes has generated excitement over its potentially promising role in understanding complex human traits. A new study has now demonstrated the utility of this approach, reporting the resequencing of a lipid metabolism gene in a large multiethnic population and definitively showing that coding variants in the gene are associated with plasma triglyceride levels.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Service, R.F. Science 311, 1544–1546 (2006).

    Article  CAS  Google Scholar 

  2. Cohen, J. et al. Nat. Genet. 37, 161–165 (2005).

    Article  CAS  Google Scholar 

  3. Cohen, J.C. et al. Proc. Natl. Acad. Sci. USA 103, 1810–1815 (2006).

    Article  CAS  Google Scholar 

  4. Cohen, J.C. et al. Science 305, 869–871 (2004).

    Article  CAS  Google Scholar 

  5. Romeo, S. et al. Nat. Genet. 39, 513–516 (2007).

    Article  CAS  Google Scholar 

  6. Kimchi-Safarty, C. et al. Science 315, 525–528 (2007).

    Article  Google Scholar 

  7. Nackley, A.G. et al. Science 314, 1930–1933 (2006).

    Article  CAS  Google Scholar 

  8. Duerr, R.H. et al. Science 314, 1461–1464 (2006).

    Article  CAS  Google Scholar 

  9. Hampe, J. et al. Nat. Genet. 39, 207–211 (2007).

    Article  CAS  Google Scholar 

  10. Li, M. et al. Nat. Genet. 38, 1049–1054 (2006).

    Article  CAS  Google Scholar 

  11. Maller, J. et al. Nat. Genet. 38, 1055–1059 (2006).

    Article  CAS  Google Scholar 

  12. Arking, D.E. et al. Nat. Genet. 38, 644–651 (2006).

    Article  CAS  Google Scholar 

  13. Grant, S.F. et al. Nat. Genet. 38, 320–323 (2006).

    Article  CAS  Google Scholar 

  14. Sladek, R. et al. Nature 445, 881–885 (2007).

    Article  CAS  Google Scholar 

  15. Graham, R.R. et al. Nat. Genet. 38, 550–555 (2006).

    Article  CAS  Google Scholar 

  16. Nadeau, J.H. & Topol, E.J. Nat. Genet. 38, 1095–1098 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Topol, E., Frazer, K. The resequencing imperative. Nat Genet 39, 439–440 (2007). https://doi.org/10.1038/ng0407-439

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0407-439

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing