A new study reports that two common loss-of-function mutations in the gene encoding filaggrin are important risk factors for atopic dermatitis, and interestingly, for asthma in association with atopic dermatitis, but not asthma in the absence of atopic dermatitis. These findings suggest the importance of the epidermal barrier in preventing sensitization to allergens.
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Hudson, T. Skin barrier function and allergic risk. Nat Genet 38, 399–400 (2006). https://doi.org/10.1038/ng0406-399
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DOI: https://doi.org/10.1038/ng0406-399
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