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Skin barrier function and allergic risk

A new study reports that two common loss-of-function mutations in the gene encoding filaggrin are important risk factors for atopic dermatitis, and interestingly, for asthma in association with atopic dermatitis, but not asthma in the absence of atopic dermatitis. These findings suggest the importance of the epidermal barrier in preventing sensitization to allergens.

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Figure 1: Skin barrier function and allergic risk.

Katie Ris

References

  1. Lander, E.S. & Schork, N.J. Science 265, 2037–2048 (1994).

    CAS  Article  Google Scholar 

  2. Palmer, C.N.A. et al. Nat. Genet. 38, 441–446 (2006).

    CAS  Article  Google Scholar 

  3. Smith, F.J. et al. Nat. Genet. 38, 337–342 (2006).

    CAS  Article  Google Scholar 

  4. Candi, E., Schmidt, R. & Molino, G. Nat. Rev. Mol. Cell Biol. 6, 328–340 (2005).

    CAS  Article  Google Scholar 

  5. Wan, H. et al. Clin. Exp. Allergy 31, 279–294 (2001).

    CAS  Article  Google Scholar 

  6. Wan, H. et al. J. Clin. Invest. 104, 123–133 (1999).

    CAS  Article  Google Scholar 

  7. Ginger, R.S., Blachford, S., Rowland, J., Rowson, M. & Harding, C.R. Arch. Dermatol. Res. 297, 235–241 (2005).

    CAS  Article  Google Scholar 

  8. Strid, J., Hourihane, J., Kimber, I., Callard, R. & Strobel, S. Clin. Exp. Allergy 35, 757–766 (2005).

    CAS  Article  Google Scholar 

  9. Knight, D.A. & Holgate, S.T. Respirology 8, 432–446 (2003).

    Article  Google Scholar 

Download references

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Hudson, T. Skin barrier function and allergic risk. Nat Genet 38, 399–400 (2006). https://doi.org/10.1038/ng0406-399

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  • DOI: https://doi.org/10.1038/ng0406-399

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