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Skin barrier function and allergic risk

A new study reports that two common loss-of-function mutations in the gene encoding filaggrin are important risk factors for atopic dermatitis, and interestingly, for asthma in association with atopic dermatitis, but not asthma in the absence of atopic dermatitis. These findings suggest the importance of the epidermal barrier in preventing sensitization to allergens.

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Figure 1: Skin barrier function and allergic risk.

Katie Ris


  1. Lander, E.S. & Schork, N.J. Science 265, 2037–2048 (1994).

    Article  CAS  Google Scholar 

  2. Palmer, C.N.A. et al. Nat. Genet. 38, 441–446 (2006).

    Article  CAS  Google Scholar 

  3. Smith, F.J. et al. Nat. Genet. 38, 337–342 (2006).

    Article  CAS  Google Scholar 

  4. Candi, E., Schmidt, R. & Molino, G. Nat. Rev. Mol. Cell Biol. 6, 328–340 (2005).

    Article  CAS  Google Scholar 

  5. Wan, H. et al. Clin. Exp. Allergy 31, 279–294 (2001).

    Article  CAS  Google Scholar 

  6. Wan, H. et al. J. Clin. Invest. 104, 123–133 (1999).

    Article  CAS  Google Scholar 

  7. Ginger, R.S., Blachford, S., Rowland, J., Rowson, M. & Harding, C.R. Arch. Dermatol. Res. 297, 235–241 (2005).

    Article  CAS  Google Scholar 

  8. Strid, J., Hourihane, J., Kimber, I., Callard, R. & Strobel, S. Clin. Exp. Allergy 35, 757–766 (2005).

    Article  CAS  Google Scholar 

  9. Knight, D.A. & Holgate, S.T. Respirology 8, 432–446 (2003).

    Article  Google Scholar 

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Hudson, T. Skin barrier function and allergic risk. Nat Genet 38, 399–400 (2006).

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