Corning has developed a new manufacturing process that enables high-speed, high-capacity production of microarrays. Through a unique combination of technologies, thousands of spots are deposited simultaneously, in a massively parallel manner and at high density, onto specially formulated glass slides. The process and the materials used inherently deliver a high level of array reproducibility, in terms of both physical attributes (spot size, spot volume and grid alignment) and performance attributes (sensitivity, dynamic range and low coefficients of variation). We will present data demonstrating the performance of arrays printed with human expressed sequence tags, and we will describe the process in detail.