News & Views | Published:

A hole in the head

Nature Genetics volume 24, pages 330331 (2000) | Download Citation

Subjects

Two studies in this issue1,2 indicate that loss-of-function mutations in the MSX2 homeobox gene result in failure of cranial fontanelle closure in both mouse and human, and that MSX2 dosage is critical to normal osteogenesis. Another study, also in this issue, indicates that a loss-of-function mutation in MSX1 results in human cleft palate3. Msx genes interact with other genes (for example, the gene encoding TGFβ3) to specify normal or cleft palate development, raising the possibilities of both prenatal diagnosis and therapeutic treatment of human cleft palate. The dose sensitivity and interaction of craniofacial genes may be the basis for generating the important subtle variations in human faces.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature Genet. 24, 387– 390 (2000).

  2. 2.

    et al. Nature Genet. 24, 391– 395 (2000).

  3. 3.

    Nature Genet. 24, 342–343 (2000).

  4. 4.

    et al. Cell 75, 443–450 (1993).

  5. 5.

    et al. Development 115, 403– 420 (1992).

  6. 6.

    & Nature Genet 6, 348–356 (1994).

  7. 7.

    & Development 125, 4325–4333 (1998).

  8. 8.

    et al. Nature Genet 13, 417– 421 (1996).

  9. 9.

    et al. Am. J. Hum. Genet 63, 557– 568 (1998).

  10. 10.

    et al. Nature Genet. 11, 409– 414 (1996).

  11. 11.

    et al. Development 126, 3869– 3879 (1999).

  12. 12.

    et al. J. Cell Sci 108, 985– 1002 (1995).

Download references

Author information

Affiliations

  1. School of Biological Sciences, University of Manchester, Stopford Building, Manchester, M13 9PT, UK. mark.ferguson@man.ac.uk

    • Mark W J Ferguson

Authors

  1. Search for Mark W J Ferguson in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/74132

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing