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Oct-4, Scene 1: the drama of mouse development

A study by Niwa et al. shows that changes in the levels of the transcription factor Oct-4 regulate the differentiation of embryonic stem cells along three different pathways. These observations suggest a possible mechanism by which Oct-4 determines the formation of the mouse pre-implantation embryo.

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References

  1. Niwa, H., Miyazaki, J. & Smith, A.G. Nature Genet. 24, 372– 376 (2000).

    Article  CAS  Google Scholar 

  2. Palmieri, S.L., Peter, W., Hess, H. & Schöler, H.R. Dev. Biol. 166, 259–267 ( 1994).

    Article  CAS  Google Scholar 

  3. Pesce, M., Gross, M.K. & Schöler, H.R. Bioessays 20, 722– 732 (1998).

    Article  CAS  Google Scholar 

  4. Nichols, J. et al. Cell 95, 379–391 (1998).

    Article  CAS  Google Scholar 

  5. Ambrosetti, D.C., Basilico, C. & Dailey, L. Mol. Cell. Biol. 17, 6321– 6329 (1997).

    Article  CAS  Google Scholar 

  6. Brehm, A. et al. Mol. Cell. Biol. 19, 2635– 2643 (1999).

    Article  CAS  Google Scholar 

  7. Williams, R.L. et al. Nature 336, 684–687 (1988).

    Article  CAS  Google Scholar 

  8. Stewart, C.L. et al Nature 359, 76–79 (1992).

    Article  CAS  Google Scholar 

  9. Thomson, J.A. et al Science 282, 1145–1147 (1998).

    Article  CAS  Google Scholar 

  10. Gardiner, R.L. Development 124, 289–301 (1997).

    Google Scholar 

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Stewart, C. Oct-4, Scene 1: the drama of mouse development. Nat Genet 24, 328–330 (2000). https://doi.org/10.1038/74129

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