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Oct-4, Scene 1: the drama of mouse development

Nature Genetics volume 24, pages 328330 (2000) | Download Citation

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A study by Niwa et al. shows that changes in the levels of the transcription factor Oct-4 regulate the differentiation of embryonic stem cells along three different pathways. These observations suggest a possible mechanism by which Oct-4 determines the formation of the mouse pre-implantation embryo.

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Affiliations

  1. Laboratory of Cancer and Developmental Biology, National Cancer Institute - ICRDC, Frederick, Maryland 21702, USA. stewartc@nciferf.gov

    • Colin L Stewart

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DOI

https://doi.org/10.1038/74129

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