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A twist on admixture mapping

Nature Genetics volume 43, pages 178179 (2011) | Download Citation

A new study uses genome-wide SNP genotypes to identify a subset of children undergoing therapy for acute lymphoblastic leukemia that are at increased risk for relapse. Borrowing from the classical approach of admixture mapping, the work shows how genome-wide assessment of genetic ancestry can be used as a biomarker for disease outcome.

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References

  1. 1.

    et al. J. Am. Med. Assoc. 290, 2008–2014 (2003).

  2. 2.

    et al. Nat. Genet. 43, 237–241 (2011).

  3. 3.

    et al. Nat. Genet. 38, 904–909 (2006).

  4. 4.

    Am. J. Hum. Genet. 6, 26–33 (1954).

  5. 5.

    et al. Am. J. Hum. Genet. 74, 1001–1013 (2004).

  6. 6.

    et al. Am. J. Hum. Genet. 79, 640–649 (2006).

  7. 7.

    et al. Am. J. Hum. Genet. 80, 1024–1036 (2007).

  8. 8.

    et al. Am. J. Hum. Genet. 80, 1171–1178 (2007).

  9. 9.

    et al. Annu. Rev. Genomics Hum. Genet. 11, 65–89 (2010).

  10. 10.

    et al. Nat. Genet. 41, 1001–1005 (2009).

  11. 11.

    et al. Nature 447, 655–660 (2007).

  12. 12.

    et al. PLoS Genet. 5, e1000519 (2009).

  13. 13.

    et al. Am. J. Hum. Genet. 81, 626–633 (2007).

  14. 14.

    et al. Am. J. Hum. Genet. 86, 23–33 (2010).

  15. 15.

    et al. J. Asthma 44, 639–648 (2007).

Download references

Author information

Affiliations

  1. Stephen J. Chanock is at the Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

    • Stephen J Chanock

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Stephen J Chanock.

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DOI

https://doi.org/10.1038/ng0311-178

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