Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

New insights into oncogenic stress

Expression of oncogenes in otherwise normal cells often leads to the activation of anti-oncogenic pathways through a poorly understood process described as 'oncogenic stress'. A new study implicates the Jnk pathway signaling in the activation of p53 in response to both K-Ras and Neu oncogene expression.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pathways leading to cell cycle arrest due to oncogenic stress.


  1. Serrano, M. et al. Cell 88, 593–602 (1997).

    Article  CAS  Google Scholar 

  2. Michaloglou, C. et al. Nature 436, 720–724 (2005).

    Article  CAS  Google Scholar 

  3. Dankort, D. et al. Nat. Genet. 41, 544–552 (2009).

    Article  CAS  Google Scholar 

  4. Schramek, D. et al. Nat. Genet. 43, 212–219 (2011).

    Article  CAS  Google Scholar 

  5. Bode, A.M. & Dong, Z. Mol. Carcinog. 46, 591–598 (2007).

    Article  CAS  Google Scholar 

  6. Tournier, C. et al. Mol. Cell. Biol. 19, 1569–1581 (1999).

    Article  CAS  Google Scholar 

  7. MacPherson, D. et al. EMBO J. 23, 3689–3699 (2004).

    Article  CAS  Google Scholar 

  8. Bartkova, J. et al. Nature 434, 864–870 (2005).

    Article  CAS  Google Scholar 

  9. Chao, C. et al. EMBO J. 25, 2615–2622 (2006).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Christophorou, M.A. et al. Nature 443, 214–217 (2006).

    Article  CAS  Google Scholar 

  11. Efeyan, A. & Serrano, M. Cell Cycle 6, 1006–1010 (2007).

    Article  CAS  Google Scholar 

  12. Meek, D.W. Nat. Rev. Cancer 9, 714–723 (2009).

    Article  CAS  Google Scholar 

  13. Tournier, C. et al. Genes Dev. 15, 1419–1426 (2001).

    Article  CAS  Google Scholar 

  14. Kuilman, T. et al. Cell 133, 1019–1031 (2008).

    Article  CAS  Google Scholar 

  15. Coppé, J.P. et al. PLoS Biol. 6, 2853–2868 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Kevin M Haigis or Alejandro Sweet-Cordero.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haigis, K., Sweet-Cordero, A. New insights into oncogenic stress. Nat Genet 43, 177–178 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer