Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Deciphering genetic susceptibility to frontotemporal lobar dementia

Nature Genetics volume 42, pages 189–190 (2010)Cite this article

Subjects

A genome-wide association study has identified a new genetic susceptibility factor for a subtype of frontotemporal lobar dementia characterized by TDP-43 inclusions. The work illustrates how high-quality phenotyping can increase power to detect risk alleles for rare heterogeneous diseases.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Brain pathology in frontotemporal lobar dementia.

References

  1. Lambert, J.C. et al. Nat. Genet. 41, 1094–1099 (2009).

    Article  CAS  Google Scholar 

  2. Harold, D. et al. Nat. Genet. 41, 1088–1093 (2009).

    Article  CAS  Google Scholar 

  3. Satake, W. et al. Nat. Genet. 41, 1303–1307 (2009).

    Article  CAS  Google Scholar 

  4. Simón-Sánchez, J. et al. Nat. Genet. 41, 1308–1312 (2009).

    Article  Google Scholar 

  5. Van Deerlin, V.M. et al. Nat. Genet. 42, 234–239 (2010).

    Article  CAS  Google Scholar 

  6. Rosso, S.M. et al. Brain 126, 2016–2022 (2003).

    Article  Google Scholar 

  7. Snowden, J., Neary, D. & Mann, D. Acta Neuropathol. 114, 31–38 (2007).

    Article  Google Scholar 

  8. Le Ber, I. et al. Brain 131, 732–746 (2008).

    Article  Google Scholar 

  9. Hutton, M. et al. Nature 393, 702–705 (1998).

    Article  CAS  Google Scholar 

  10. Cruts, M. et al. Nature 442, 920–924 (2006).

    Article  CAS  Google Scholar 

  11. Baker, M. et al. Nature 442, 916–919 (2006).

    Article  CAS  Google Scholar 

  12. Le Ber, I. et al. Hum. Mutat. 28, 846–855 (2007).

    Article  CAS  Google Scholar 

  13. Watts, G.D. et al. Nat. Genet. 36, 377–381 (2004).

    Article  CAS  Google Scholar 

  14. Skibinski, G. et al. Nat. Genet. 37, 806–808 (2005).

    Article  CAS  Google Scholar 

  15. Neumann, M. et al. Science 314, 130–133 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jean-Charles Lambert and Philippe Amouyel are at Inserm U744, Institut Pasteur de Lille and Université de Lille Nord de France, Lille, France.,

    Jean-Charles Lambert & Philippe Amouyel

Authors
  1. Jean-Charles Lambert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philippe Amouyel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jean-Charles Lambert or Philippe Amouyel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lambert, JC., Amouyel, P. Deciphering genetic susceptibility to frontotemporal lobar dementia. Nat Genet 42, 189–190 (2010). https://doi.org/10.1038/ng0310-189

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0310-189

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing