FGF receptors have been implicated in a number of syndromes that involve skeletal disorders. A new study in mice has identified a spontaneous mutation in Fgf9 with reduced activity but increased diffusion through tissues resulting in a gain-of-function phenotype comparable to those due to activating mutations in genes encoding FGF receptors.
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Spicer, D. FGF9 on the move. Nat Genet 41, 272–273 (2009). https://doi.org/10.1038/ng0309-272
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DOI: https://doi.org/10.1038/ng0309-272
