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Processing the H3K36me3 signature

Nature Genetics volume 41, pages 270–271 (2009)Cite this article

The global patterning of histone lysine methylation has been scrutinized over the years in an effort to uncover unique features indicative of chromatin function. A study in Caenorhabditis elegans now shows that nucleosomes covering exons and introns on active genes are differentially marked by H3K36 trimethylation, suggesting a new mode of communication between chromatin and pre-mRNA processing.

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Figure 1: The U1 snRNP and SR splicing proteins are recruited to active genes in part via RNA polymerase II (RNAPII), and CHD1 assists in U2 snRNP recruitment.

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Authors and Affiliations

  1. Robert J. Sims III is at Constellation Pharmaceuticals, Cambridge, Massachusetts 02139, USA.,

    Robert J Sims III

  2. Danny Reinberg is at the Department of Biochemistry, New York University School of Medicine, New York 10016 USA. reinbd01@nyumc.org robert.sims@constellationpharma.com,

    Danny Reinberg

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  1. Robert J Sims III
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  2. Danny Reinberg
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Sims III, R., Reinberg, D. Processing the H3K36me3 signature. Nat Genet 41, 270–271 (2009). https://doi.org/10.1038/ng0309-270

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