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MicroRNAs in facial development

Cranial neural crest cell migration is a prerequisite for normal craniofacial morphogenesis in animals. A new study shows that the movement of a specific subset of cranial neural crest cells is exquisitely sensitive to concentrations of a microRNA that targets platelet-derived growth factor receptor alpha mRNA.

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Figure 1: Mirn140 attenuates Pdgfra signaling in palatal precursors.


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Clouthier, D. MicroRNAs in facial development. Nat Genet 40, 268–269 (2008).

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