Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Disentangling the roots of inherited hair disorders

Rare syndromes offer unique opportunities to gain insight into central physiological processes. By deciphering the genetic basis of two rare inherited diseases, two studies identify a key role for P2Y5, a G protein–coupled receptor, in hair follicle development.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Deciphering the pathogenesis of inherited nonsyndromic forms of alopecias reveals pathways regulating hair development.


  1. Pasternack, S.M. et al. Nat. Genet. 40, 329–335 (2008).

    Article  CAS  Google Scholar 

  2. Shimomura, Y. et al. Nat. Genet. 40, 335–339 (2008).

    Article  CAS  Google Scholar 

  3. Webb, T.E., Kaplan, M.G. & Barnard, E.A. Biochem. Biophys. Res. Commun. 219, 105–110 (1996).

    Article  CAS  Google Scholar 

  4. Schlake, T. Semin. Cell Dev. Biol. 18, 267–273 (2007).

    Article  CAS  Google Scholar 

  5. Kazantseva, A. et al. Science 314, 982–985 (2006).

    Article  CAS  Google Scholar 

  6. Lai-Cheong, J.E., Arita, K. & McGrath, J.A. J. Invest. Dermatol. 127, 2713–2725 (2007).

    Article  CAS  Google Scholar 

  7. Schweizer, J. J. Invest. Dermatol. 126, 1216–1219 (2006).

    Article  CAS  Google Scholar 

  8. Ahmad, W. et al. Science 279, 720–724 (1998).

    Article  CAS  Google Scholar 

  9. Cichon, S. et al. Hum. Mol. Genet. 7, 1671–1679 (1998).

    Article  CAS  Google Scholar 

  10. Cserhalmi-Friedman, P.B., Panteleyev, A.A. & Christiano, A.M. Exp. Dermatol. 13, 155–162 (2004).

    Article  CAS  Google Scholar 

  11. Takahashi, T., Kamimura, A., Hamazono-Matsuoka, T. & Honda, S. J. Invest. Dermatol. 121, 448–456 (2003).

    Article  CAS  Google Scholar 

  12. Kljuic, A. et al. Cell 113, 249–260 (2003).

    Article  CAS  Google Scholar 

  13. Sprecher, E. et al. Nat. Genet. 29, 134–136 (2001).

    Article  CAS  Google Scholar 

  14. Levy-Nissenbaum, E. et al. Nat. Genet. 34, 151–153 (2003).

    Article  CAS  Google Scholar 

  15. Smith, F. Am. J. Clin. Dermatol. 4, 347–364 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sprecher, E. Disentangling the roots of inherited hair disorders. Nat Genet 40, 265–266 (2008).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing