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DNMT1 knockout delivers a strong blow to genome stability and cell viability

Nature Genetics volume 39, pages 289290 (2007) | Download Citation

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The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

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Affiliations

  1. Kevin D. Brown and Keith D. Robertson are in the Department of Biochemistry and Molecular Biology and the University of Florida–Shands Cancer Center, University of Florida, Box 100245, 1600 S.W. Archer Rd., Gainesville, Florida 32610, USA. keithr@ufl.edu

    • Kevin D Brown
    •  & Keith D Robertson

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Competing interests

The authors declare no competing financial interests.

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DOI

https://doi.org/10.1038/ng0307-289

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