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Think globally, act locally

Nature Genetics volume 39, pages 287289 (2007) | Download Citation

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In the nematode Caenorhabditis elegans, dosage compensation is mediated by a subtle twofold downregulation of both X chromosomes. A new study provides a significant advance in our understanding of how the X is targeted for dosage compensation and how this global regulation is integrated with regulation of the expression of each gene.

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Author information

Affiliations

  1. Valerie Reinke is in the Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA. valerie.reinke@yale.edu

    • Valerie Reinke

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Competing interests

The author declares no competing financial interests.

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DOI

https://doi.org/10.1038/ng0307-287

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