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Think globally, act locally

Nature Genetics volume 39, pages 287–289 (2007)Cite this article

In the nematode Caenorhabditis elegans, dosage compensation is mediated by a subtle twofold downregulation of both X chromosomes. A new study provides a significant advance in our understanding of how the X is targeted for dosage compensation and how this global regulation is integrated with regulation of the expression of each gene.

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Figure 1: The dosage compensation complex (DCC), containing both DPY-27 and SDC-3 (dark green), binds strongly to a recruitment site on the X and spreads from that location to transcriptional start sites of neighboring genes, sometimes losing SDC-3 on the way (light green).

Katie Ris

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Authors and Affiliations

  1. Valerie Reinke is in the Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA. valerie.reinke@yale.edu,

    Valerie Reinke

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  1. Valerie Reinke
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The author declares no competing financial interests.

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Reinke, V. Think globally, act locally. Nat Genet 39, 287–289 (2007). https://doi.org/10.1038/ng0307-287

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