A new approach that scans the modification states of histones along the chromosome allows the identification of enhancer elements in the complex genomes of higher eukaryotes. This is an important step in the functional annotation of the genome.
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References
Spitz, F., Gonzalez, F. & Duboule, D. Cell 113, 405–417 (2003).
Forrester, W.C., Thompson, C., Elder, J.T. & Groudine, M.A. Proc. Natl. Acad. Sci. USA 83, 1359–1363 (1986).
Pennacchio, L.A. et al. Nature 444, 499–502 (2006).
Heintzman, N.D. et al. Nat. Genet. 39, 311–318 (2007).
Wu, C., Bingham, P.M., Livak, K.J., Holmgren, R. & Elgin, S.C. Cell 16, 797–806 (1979).
Felsenfeld, G. & Groudine, M. Nature 421, 448–453 (2003).
Pokholok, D.K. et al. Cell 122, 517–527 (2005).
Schubeler, D. et al. Genes Dev. 18, 1263–1271 (2004).
Follows, G.A. et al. Genome Res. 16, 1310–1319 (2006).
Roh, T.Y., Wei, G., Farrell, C.M. & Zhao, K. Genome Res. 17, 74–81 (2007).
Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Science 295, 1306–1311 (2002).
Carroll, J.S. et al. Cell 122, 33–43 (2005).
Simonis, M. et al. Nat. Genet. 38, 1348–1354 (2006).
Zhao, Z. et al. Nat. Genet. 38, 1341–1347 (2006).
Ruthenberg, A.J., Allis, C.D. & Wysocka, J. Mol. Cell 25, 15–30 (2007).
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Schübeler, D. Enhancing genome annotation with chromatin. Nat Genet 39, 284–285 (2007). https://doi.org/10.1038/ng0307-284
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DOI: https://doi.org/10.1038/ng0307-284
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Genome-wide search for Zelda-like chromatin signatures identifies GAF as a pioneer factor in early fly development
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