In the current era of large-scale cancer genome sequencing, the interpretation of somatic sequence alterations is a formidable challenge. A new study of known mutations represents an important step in cataloging somatic mutations in individual tumors.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy
Acta Neuropathologica Communications Open Access 22 April 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Perou, C.M. et al. Nature 406, 747–752 (2000).
Alizadeh, A.A. et al. Nature 403, 503–511 (2000).
Risch, N.J. Nature 405, 847–856 (2000).
Weir, B., Zhao, X. & Meyerson, M. Cancer Cell 6, 433–438 (2004).
Stephens, P. et al. Nat. Genet. 37, 590–592 (2005).
Thomas, R.K. Nat. Genet. 39, 347–351 (2007).
Davies, H. et al. Nature 417, 949–954 (2002).
Maley, C.C. et al. Nat. Genet. 38, 468–473 (2006).
Bardelli, A. et al. Science 300, 949 (2003).
Wang, Z. et al. Science 304, 1164–1166 (2004).
Sjoblom, T. et al. Science 314, 268–274 (2006).
Kapranov, P. et al. Science 296, 916–919 (2002).
Cheng, J. et al. Science 308, 1149–1154 (2005).
Calin, G.A. & Croce, C.M. Nat. Rev. Cancer 6, 857–866 (2006).
Chanock, S. et al. Breast Cancer Res. 9, R5 (2007).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Chanock, S., Thomas, G. The devil is in the DNA. Nat Genet 39, 283–284 (2007). https://doi.org/10.1038/ng0307-283
Issue Date:
DOI: https://doi.org/10.1038/ng0307-283
This article is cited by
-
TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy
Acta Neuropathologica Communications (2016)
-
SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms
Acta Biotheoretica (2016)
-
Mutation profiling in tumor samples using the Sequenom OncoCarta™ Panel
Nature Methods (2009)
-
A map of human cancer signaling
Molecular Systems Biology (2007)