Mutations in components of the planar cell polarity pathway in mammals give rise to neural tube defects, anomalous cochlear hair cell stereocilia and kidney cysts. A new study suggests that two planar cell polarity components initially characterized in flies are required for ciliogenesis and Hedgehog signaling in frog embryos, providing insights into the mechanisms governing positioning and growth of the ciliary axoneme.
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Katie Ris
References
Ueno, N. & Greene, N.D. Birth Defects Res. C Embryo Today 69, 318–324 (2003).
Bale, A.E. Annu. Rev. Genomics Hum. Genet. 3, 47–65 (2002).
Ross, A.J. et al. Nat. Genet. 37, 1135–1140 (2005).
Simons, M. et al. Nat. Genet. 37, 537–543 (2005).
Park, T., Haigo, S. & Wallingford, J. Nat. Genet. 38, 303–311 (2006).
Hagiwara, H. Ital. J. Anat. Embryol. 100 (Suppl.), 451–459 (1995).
Adler, P.N., Zhu, C. & Stone, D. Curr. Biol. 14, 2046–2051 (2004).
Lee, H. & Adler, P.N. Genetics 160, 1535–1547 (2002).
Nobes, C.D. & Hall, A. Cell 81, 53–62 (1995).
Strutt, D.I., Weber, U. & Mlodzik, M. Nature 387, 292–295 (1997).
Montcouquiol, M. et al. Nature 423, 173–177 (2003).
Denman-Johnson, K. & Forge, A. J. Neurocytol. 28, 821–835 (1999).
Haycraft, C.J. et al. PLoS Genet. 1, e53 (2005).
Corbit, K.C. et al. Nature 437, 1018–1021 (2005).
May, S.R. et al. Dev. Biol. 287, 378–389 (2005).
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Beales, P. Hedgehogs on the road to polarity. Nat Genet 38, 277–279 (2006). https://doi.org/10.1038/ng0306-277
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DOI: https://doi.org/10.1038/ng0306-277
