Upending the hair follicle

A new study profiles microRNA (miRNA) expression in mouse epidermis and hair follicles and examines the requirement for these miRNAs during normal embryonic development. In the absence of Dicer-dependent miRNA production, hair follicles evaginate rather than invaginate, revealing an unexpected role for miRNAs in regulating hair follicle morphogenesis.

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Figure 1: A mature hair follicle in the anagen or growth phase is shown at left with its concentric layers of the outer root sheath (ORS, blue), inner root sheath (IRS, drab green) and hair shaft (tan).

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Morgan, B. Upending the hair follicle. Nat Genet 38, 273–274 (2006). https://doi.org/10.1038/ng0306-273

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