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Dynamin in disease

Dynamins are dynamic scaffolding proteins that function in membrane trafficking. A new study shows that mutations in the gene encoding dynamin 2 underlie a distinct form of peripheral neuropathy, establishing the first link between dynamins and human disease.

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Figure 1: The domain structure of DNM2 showing the highly conserved GTPase domain and the downstream pleckstrin homology (PH), GED and proline-arginine-rich (PRD) regions.

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McNiven, M. Dynamin in disease. Nat Genet 37, 215–216 (2005). https://doi.org/10.1038/ng0305-215

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