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SWItching off methylated DNA

The mechanism by which cytosine methylation stably represses transcription is of great interest. A new study provides evidence associating DNA methylation, MeCP2 and the SWI/SNF chromatin-remodeling factor, implicating local chromatin architecture in DNA methylation–dependent transcriptional repression.

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Figure 1: One potential scenario by which MeCP2 and the SWI/SNF complex might cooperate in establishment or maintenance of transcriptional repression at a methylated locus.


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Wade, P. SWItching off methylated DNA. Nat Genet 37, 212–213 (2005).

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