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Reply to "Is Tsix repression of Xist specific to mouse?"

Nature Genetics volume 33, pages 337–338 (2003)Cite this article

—In reply

Migeon argues that the regulation of X-chromosome inactivation differs considerably between mice and humans. Specifically, she suggests that antisense regulation of Xist by Tsix occurs only in mice, where the antisense Tsix blocks Xist expression during both imprinted and random X inactivation1,2,3,4,5,6,7. Migeon and colleagues have shown that the human X-inactivation center also expresses a transcript antisense to XIST8, but conclude that human TSIX cannot be functional for two reasons: (i) TSIX truncates within XIST intron 4 and (ii) TSIX is sometimes co-expressed with XIST in differentiated cells9. It is thus argued that human females are TSIX-deficient and that TSIX cannot be a regulator of human X inactivation.

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  1. Department of Molecular Biology, Department of Genetics, Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, Massachusetts, USA

    Jeannie T. Lee

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  1. Jeannie T. Lee
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Lee, J. Reply to "Is Tsix repression of Xist specific to mouse?". Nat Genet 33, 337–338 (2003). https://doi.org/10.1038/ng0303-337b

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