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Multigenic control of Listeria monocytogenes susceptibility in mice

Nature Genetics volume 27, pages 259–260 (2001)Cite this article

Abstract

We have used a novel quantitative trait locus model to study the genetics of survival of F2 progeny of susceptible BALB/cByJ and resistant C57BL/6ByJ mice that have been infected with Listeria monocytogenes. This allowed us to map modifiers of L. monocytogenes susceptibility to chromosomes 5 and 13.

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Figure 1: Progression of listeriosis.
Figure 2: Mapping results.

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Acknowledgements

We thank A. Cooper for help with histopathologic studies; T. Wright for technical support; and J. Growney, J. Watters and Å. Vik for valuable input. V.L.B. was supported by a fellowship from Irvington Institute for Immunological Research.

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Authors and Affiliations

  1. Howard Hughes Medical Institute/Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Victor L. Boyartchuk & William F. Dietrich

  2. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Sarah E.F. D'Orazio & Michael N. Starnbach

  3. Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA

    Karl W. Broman

  4. Department of Pathology, Faulkner Hospital, Jamaica Plain, Massachusetts, USA

    Rebecca E. Mosher

Authors
  1. Victor L. Boyartchuk
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  2. Karl W. Broman
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  3. Rebecca E. Mosher
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  4. Sarah E.F. D'Orazio
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  5. Michael N. Starnbach
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  6. William F. Dietrich
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Correspondence to William F. Dietrich.

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Boyartchuk, V., Broman, K., Mosher, R. et al. Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet 27, 259–260 (2001). https://doi.org/10.1038/85812

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