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Axin and hepatocellular carcinomas

A gene (AXIN1) encoding another component of the Wnt-signalling pathway is reported to be mutated in human tumours, underscoring the oncogenic consequences of inappropriate activation of developmental signalling pathways later in life. Inhibitors of these signals therefore represent potential agents with which to treat cancer.

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Figure 1
Figure 2: Schematic representation of the Wnt-signalling cascade.

References

  1. Nakamura, Y. et al. Nature Genet. 24, 245– 250 (2000).

    Article  Google Scholar 

  2. Nusse, R. & Varmus, H.E. Cell 31, 99–109 (1982).

    Article  CAS  Google Scholar 

  3. Rijsewijk, F. et al. Cell 50, 649–657 (1987).

    Article  CAS  Google Scholar 

  4. McMahon, A.P. & Moon, R. Cell 58, 1075 –1084 (1989).

    Article  CAS  Google Scholar 

  5. Cadigan, K.M. & Nusse, R. Genes Dev. 11, 3286–3305 (1997).

    Article  CAS  Google Scholar 

  6. Kinzler, K.W. & Vogelstein, B. Cell 87, 159–170 (1996).

    Article  CAS  Google Scholar 

  7. Korinek, V. et al. Science 275, 1784– 1787 (1997).

    Article  CAS  Google Scholar 

  8. Korinek, V. et al. Nature Genet. 19, 279– 283 (1998).

    Article  Google Scholar 

  9. Morin, P.J. et al. Science 275, 1787– 1790 (1997).

    Article  CAS  Google Scholar 

  10. Rubinfeld, B. et al. Science 275, 1790– 1792 (1997).

    Article  CAS  Google Scholar 

  11. Roose, J. & Clevers, H. Biochim. Biophys. Acta 1424, 23–37 (1999).

    Google Scholar 

  12. Zeng, L. et al. Cell 90, 181–192 (1997).

    Article  CAS  Google Scholar 

  13. Behrens, J. et al. Science 280, 596–599 (1998).

    Article  CAS  Google Scholar 

  14. Hart, M.J. et al. Curr. Biol. 8, 573– 581 (1998).

    Article  CAS  Google Scholar 

  15. Nakamura, T. et al. Genes Cells 3, 395– 403 (1998).

    Article  CAS  Google Scholar 

  16. Molenaar, M. et al. Cell 86, 391–399 (1996).

    Article  CAS  Google Scholar 

Download references

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Clevers, H. Axin and hepatocellular carcinomas. Nat Genet 24, 206–208 (2000). https://doi.org/10.1038/73396

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