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Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

Nature Genetics volume 21, pages 213–215 (1999)Cite this article

Abstract

Complex disorders such as diabetes, cardiovascular disease, asthma, hypertension and psychiatric illnesses account for a large and disproportionate share of health care costs, but remain poorly characterized with respect to aetiology. The transmission of such disorders is complex, reflecting the actions and interactions of multiple genetic and environmental factors. Genetic analyses that allow for the simultaneous consideration of susceptibility from multiple regions may improve the ability to map genes for complex disorders1,2, but such analyses are currently computationally intensive and narrowly focused. We describe here an approach to assessing the evidence for statistical interactions between unlinked regions that allows multipoint allele–sharing analysis to take the evidence for linkage at one region into account in assessing the evidence for linkage over the rest of the genome. Using this method, we show that the interaction of genes on chromosomes 2 (NIDDM1) and 15 (near CYP19) makes a contribution to susceptibility to type 2 diabetes in Mexican Americans from Starr County, Texas.

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Figure 1: Interaction between NIDDM1 and CYP19.

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Acknowledgements

This research was supported in part by National Institutes of Health grants GM–46800, DK–20595, DK–47481, DK–47486, DK–47487 and DK–47494.

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Authors and Affiliations

  1. Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, 60637, Illinois, USA

    Nancy J. Cox & Graeme I. Bell

  2. Department of Statistics, The University of Chicago, 5841 South Maryland Avenue, Chicago, 60637, Illinois, USA

    Dan L. Nicolae & Augustine Kong

  3. Department of Biochemistry and Molecular Biology, and Howard Hughes Medical Institute, The University of Chicago, 5841 South Maryland Avenue, Chicago, 60637, Illinois, USA

    Graeme I. Bell

  4. deCODE Genetics, Lynghals 1, Reykjavik, 110, Iceland

    Mike Frigge, Dan L. Nicolae & Augustine Kong

  5. Virginia Mason Research Center, 1000 Seneca Street, Seattle, 98101, Washington

    Patrick Concannon

  6. Department of Immunology, University of Washington School of Medicine, Seattle, 98195, Washington, USA

    Patrick Concannon

  7. Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, 77030, Texas, USA

    Craig L. Hanis

Authors
  1. Nancy J. Cox
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  2. Mike Frigge
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  3. Dan L. Nicolae
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  4. Patrick Concannon
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  5. Craig L. Hanis
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  6. Graeme I. Bell
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  7. Augustine Kong
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Correspondence to Nancy J. Cox.

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Cox, N., Frigge, M., Nicolae, D. et al. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet 21, 213–215 (1999). https://doi.org/10.1038/6002

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