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A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

Nature Genetics volume 6, pages 146–151 (1994)Cite this article

Abstract

The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the ETS family member, FLI–1. This results in the expression of a chimaeric protein containing the amino–terminal portion of EWS fused to the ETS DMA–binding domain of FLI–1. We have identified a second Ewing's sarcoma translocation, t(21;22)(q22;q12), that fuses EWS to a different ETS family member, the ERG gene located on band 21q22. Identical EWS nucleotide sequences found in the EWS/FLI–1 fusion transcripts are fused to portions of ERG encoding an ETS DNA–binding domain resulting in expression of a hybrid EWS/ERG protein. These findings suggest that fusion of EWS to different members of the ETS family of transcription factor genes may result in the expression of similar disease phenotypes.

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Author notes

  1. Poul H.B. Sorensen

    Present address: Department of Pathology, British Columbia's Children's Hospital, Vancouver, British Columbia, Canada, V6H 3V4

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Childrens Hospital of Los Angeles/University of Southern California, Los Angeles, California, 90027, USA

    Poul H.B. Sorensen, Dolores Lopez-Terrada, Xian F. Liu & Timothy J. Triche

  2. Department of Molecular Biology Institute and Johnson Comprehensive Cancer Center, Division of Hematohgy, Oncology University of California at Los Angeles, Los Angeles, California, 90024, USA

    Stephen L. Lessnick & Christopher T. Denny

  3. Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, Division of Hematohgy, Oncology University of California at Los Angeles, Los Angeles, California, 90024, USA

    Christopher T. Denny

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  1. Poul H.B. Sorensen
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Sorensen, P., Lessnick, S., Lopez-Terrada, D. et al. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG. Nat Genet 6, 146–151 (1994). https://doi.org/10.1038/ng0294-146

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