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Inborn variation in metabolism

Advances in analytical biochemistry have recently made it possible to obtain global snapshots of metabolism. A new study couples such technology with genome-wide genetic analysis to explore inherited variation in human metabolism.

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Figure 1: Mendelian randomization experiment to test whether genetic alteration of a metabolic pathway plays a causal role in disease.


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Correspondence to Vamsi K Mootha or Joel N Hirschhorn.

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Mootha, V., Hirschhorn, J. Inborn variation in metabolism. Nat Genet 42, 97–98 (2010).

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