Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Deregulation of H3K27 methylation in cancer

A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Deregulation of H3K27 methylation in cancer.

References

  1. Morin, R.D. et al. Nat. Genet. 42, 181–185 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Barski, A. et al. Cell 129, 823–837 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Lachner, M., O'Sullivan, R.J. & Jenuwein, T. J. Cell Sci. 116, 2117–2124 (2003).

    Article  CAS  PubMed  Google Scholar 

  4. Bernstein, B.E. et al. Cell 125, 315–326 (2006).

    CAS  PubMed  Google Scholar 

  5. Kouzarides, T. Cell 128, 693–705 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Hansen, K.H. et al. Nat. Cell Biol. 10, 1291–1300 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. Bamford, S. et al. Br. J. Cancer 91, 355–358 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Simon, J.A. & Lange, C.A. Mutat. Res. 647, 21–29 (2008).

    Article  CAS  PubMed  Google Scholar 

  9. Cao, Q. et al. Oncogene 27, 7274–7284 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Yu, J. et al. Cancer Res. 67, 10657–10663 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. Puppe, J. et al. Breast Cancer Res. 11, R63 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Sander, S. et al. Blood 112, 4202–4212 (2008).

    Article  CAS  PubMed  Google Scholar 

  13. Lan, F. et al. Nature 449, 689–694 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. van Haaften, G. et al. Nat. Genet. 41, 521–523 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Su, I.H. et al. Nat. Immunol. 4, 124–131 (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan D Licht.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Martinez-Garcia, E., Licht, J. Deregulation of H3K27 methylation in cancer. Nat Genet 42, 100–101 (2010). https://doi.org/10.1038/ng0210-100

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0210-100

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing