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Two ways to make an mtDNA bottleneck

Nature Genetics volume 40, pages 134–135 (2008)Cite this article

Rapid changes in mitochondrial DNA allele frequency between generations have been explained by an 'mtDNA bottleneck' in the germ line, and it has recently been proposed that mtDNA aggregates, or nucleoids, drive such a bottleneck. Now, a new study finds a sharp reduction in mtDNA content in the germ line and suggests that such reduction alone may account for the bottleneck effect.

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Figure 1: How is the mitochondrial bottleneck tightened?

Katie Ris-Vicari

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Authors and Affiliations

  1. Konstantin Khrapko is at Beth Israel Deaconess Medical Center and Harvard Medical School, 21-27 Burlington Avenue, Boston, Massachusetts 02215, USA. khrapko@hms.harvard.edu,

    Konstantin Khrapko

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  1. Konstantin Khrapko
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Khrapko, K. Two ways to make an mtDNA bottleneck. Nat Genet 40, 134–135 (2008). https://doi.org/10.1038/ng0208-134

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