Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hypoxic reprogramming

Many organisms have an amazing capacity to adapt to conditions of low oxygen, but the cellular mechanisms of this are poorly understood. A new study in mice has unveiled a molecular trigger that initiates a cascade of events to reprogram cellular oxygen requirements.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: General scheme for hypoxia-triggered cellular metabolic reprogramming via Phd1 and HIF-2α.

Katie Ris-Vicari

References

  1. Ramirez, J-M., Folkow, L.P. & Blix, A.S. Annu. Rev.Physiol. 69, 113–143 (2007).

    Article  CAS  Google Scholar 

  2. Andrews, M.T. Biochem. Soc. Trans. 32, 1021–1024 (2004).

    Article  CAS  Google Scholar 

  3. Semenza, G.L., Roth, P.H., Fang, H.M. & Wang, G.L. J. Biol. Chem. 269, 23757–23763 (1994).

    CAS  Google Scholar 

  4. Aragonés, J. et al. Nat. Genet. 40, 170–180 (2008).

    Article  Google Scholar 

  5. Bunn, H.F. & Poyton, R.O. Physiol. Rev. 76, 839–885 (1996).

    Article  CAS  Google Scholar 

  6. Semenza, G.L. Sci. STKE 407, cm8 (2007).

    Google Scholar 

  7. Kim, J.W., Tchernyshyov, I., Semenza, G.L. & Dang, C.V. Cell Metab. 3, 177–185 (2006).

    Article  Google Scholar 

  8. Papandreou, I., Cairns, R.A., Fontana, L., Lim, A.L. & Denko, N.C. Cell Metab. 3, 187–197 (2006).

    Article  CAS  Google Scholar 

  9. Wu, P., Peters, J.M. & Harris, R.A. Biochem. Biophys. Res. Commun. 287, 391–396 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kelly, D. Hypoxic reprogramming. Nat Genet 40, 132–134 (2008). https://doi.org/10.1038/ng0208-132

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0208-132

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing