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Pushing the envelope on lipodystrophy

Nature Genetics volume 24, pages 103–104 (2000)Cite this article

Abstract

Autosomal dominant partial lipdystrophy (PLD), in which regional adipose loss is coupled with insulin resistance, is strongly associated with missense mutations in LMNA, encoding lamin A/C—a component of the nuclear envelope. This finding indicates that other proteins and functions of the nuclear envelope may have bearing on disorders of adipose tissue and insulin action.

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Authors and Affiliations

  1. Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Brookline, 02215, Massachusetts, USA

    Jeffrey S Flier

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  1. Jeffrey S Flier
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Flier, J. Pushing the envelope on lipodystrophy. Nat Genet 24, 103–104 (2000). https://doi.org/10.1038/72734

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