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Sox9 marks adult organ progenitors

Adult stem cells play pivotal roles in self-renewing tissues but also in the post-injury repair of adult organs that normally show little proliferative activity. A new study shows that Sox9 marks a putative adult stem cell population that contributes to the self-renewal and repair of the liver, exocrine pancreas and intestine, three organs of endodermal origin.

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Figure 1: Schematic drawing illustrating the structure of the adult biliary tree.

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Acknowledgements

H.C. is supported by Koningin Wilhelmina Fonds (KWF) program grant # PF-HUBR-2007-3956. M.H. is supported by an Intra-European Fellowship from the Marie Curie Actions-European commission. We thank R. Vries for helpful comments and proofreading.

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Correspondence to Hans Clevers.

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Huch, M., Clevers, H. Sox9 marks adult organ progenitors. Nat Genet 43, 9–10 (2011). https://doi.org/10.1038/ng0111-9

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