To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome. A new study demonstrates that a single protein, FoxA1, can dictate the global DNA binding profile and the transcriptional function of estrogen receptor a in breast cancer cells and in other cell types.
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The authors declare no competing financial interests.
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Cheung, E., Ruan, Y. Determination of transcription factor binding. Nat Genet 43, 11–12 (2011). https://doi.org/10.1038/ng0111-11