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Determination of transcription factor binding

To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome. A new study demonstrates that a single protein, FoxA1, can dictate the global DNA binding profile and the transcriptional function of estrogen receptor a in breast cancer cells and in other cell types.

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Figure 1: The proposed model for the role of FoxA1 in determining ERα-chromatin interactions.


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Correspondence to Yijun Ruan.

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The authors declare no competing financial interests.

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Cheung, E., Ruan, Y. Determination of transcription factor binding. Nat Genet 43, 11–12 (2011).

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