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Searching for targets of viral microRNAs

The identification of targets of virally encoded microRNAs is essential to understanding their role in the viral life cycle. A new study reports the successful use of a microarray-based approach to identify a key target of a microRNA encoded by Kaposi's sarcoma–associated herpesvirus, with implications for microRNA target identification in other contexts as well.

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  1. Pfeffer, S. et al. Science 304, 734–736 (2004).

    Article  CAS  Google Scholar 

  2. Pfeffer, S. et al. Nat. Methods 2, 269–276 (2005).

    Article  CAS  Google Scholar 

  3. Cai, X. et al. Proc. Natl. Acad. Sci. USA 102, 5570–5575 (2005).

    Article  CAS  Google Scholar 

  4. Samols, M.A., Hu, J., Skalsky, R.L. & Renne, R. J. Virol. 79, 9301–9305 (2005).

    Article  CAS  Google Scholar 

  5. Grundhoff, A., Sullivan, C.S. & Ganem, D. RNA 12, 733–750 (2006).

    Article  CAS  Google Scholar 

  6. Ziegelbauer, J.M., Sullivan, C.S. & Ganem, D. Nat. Genet. 41, 130–134 (2009).

    Article  CAS  Google Scholar 

  7. Samols, M.A. et al. PLoS Pathog. 3, e65 (2007).

    Article  Google Scholar 

  8. Skalsky, R.L. et al. J. Virol. 81, 12836–12845 (2007).

    Article  CAS  Google Scholar 

  9. Gottwein, E. et al. Nature 450, 1096–1099 (2007).

    Article  CAS  Google Scholar 

  10. Sullivan, C.S., Grundhoff, A.T., Tevethia, S., Pipas, J.M. & Ganem, D. Nature 435, 682–686 (2005).

    Article  CAS  Google Scholar 

  11. Seo, G.J., Fink, L.H., O'Hara, B., Atwood, W.J. & Sullivan, C.S. J. Virol. 82, 9823–9828 (2008).

    Article  CAS  Google Scholar 

  12. Grey, F. & Nelson, J. J. Clin. Virol. 41, 186–191 (2008).

    Article  CAS  Google Scholar 

  13. Stern-Ginossar, N. et al. Science 317, 376–381 (2007).

    Article  CAS  Google Scholar 

  14. Grey, F. et al. J. Virol. 79, 12095–12099 (2005).

    Article  CAS  Google Scholar 

  15. Lo, A.K. et al. Proc. Natl. Acad. Sci. USA 104, 16164–16169 (2007).

    Article  CAS  Google Scholar 

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Whitby, D. Searching for targets of viral microRNAs. Nat Genet 41, 7–8 (2009).

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