Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cohort studies and the genetics of complex disease

Three new studies identify nearly 20 new loci for serum lipid levels using predominantly a prospective cohort study design which also permits extensive and unbiased characterization of environmental exposures. Given the known, strong environmental influences on these traits, investigation of gene-environment interactions should be emphasized in attempts to understand the complete epidemiologic and genetic architecture of these complex traits.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Loci reported in association with any of the lipid variables (triglycerides and total, high-density lipoprotein or low-density lipoprotein cholesterol) in one, two or all three studies in the current issue3,4,5.


  1. Manolio, T.A., Brooks, L.D. & Collins, F.S. J. Clin. Invest. 118, 1590–1605 (2008).

    Article  CAS  Google Scholar 

  2. Lusis, A.J. & Pajukanta, P. Nat. Genet. 40, 129–130 (2008).

    Article  CAS  Google Scholar 

  3. Sabatti, C. et al. Nat. Genet. 41, 35–46 (2009).

    Article  CAS  Google Scholar 

  4. Aulchenko, Y.S. et al. Nat. Genet. 41, 47–55 (2009).

    Article  CAS  Google Scholar 

  5. Kathiresan, S. et al. Nat. Genet. 41, 56–65 (2009).

    Article  CAS  Google Scholar 

  6. Manolio, T.A., Bailey-Wilson, J.E. & Collins, F.S. Nat. Rev. Genet. 7, 812–820 (2006).

    Article  CAS  Google Scholar 

  7. Ordovas, J.M. et al. Circulation 106, 2315–2321 (2002).

    Article  CAS  Google Scholar 

  8. Prokopenko, I. et al. Nat. Genet. 41, 77–81 (2009).

    Article  CAS  Google Scholar 

  9. Bouatia-Naji, N. et al. Nat. Genet. 41, 89–94 (2009).

    Article  CAS  Google Scholar 

  10. Lyssenko, V. et al. Nat. Genet. 41, 82–88 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Manolio, T. Cohort studies and the genetics of complex disease. Nat Genet 41, 5–6 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing