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Cohort studies and the genetics of complex disease

Nature Genetics volume 41, pages 5–6 (2009)Cite this article

Three new studies identify nearly 20 new loci for serum lipid levels using predominantly a prospective cohort study design which also permits extensive and unbiased characterization of environmental exposures. Given the known, strong environmental influences on these traits, investigation of gene-environment interactions should be emphasized in attempts to understand the complete epidemiologic and genetic architecture of these complex traits.

Prospective cohort studies in GWAS

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Figure 1: Loci reported in association with any of the lipid variables (triglycerides and total, high-density lipoprotein or low-density lipoprotein cholesterol) in one, two or all three studies in the current issue3,4,5.

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  1. Teri A. Manolio is at the National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. manolio@nih.gov,

    Teri A Manolio

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  1. Teri A Manolio
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Manolio, T. Cohort studies and the genetics of complex disease. Nat Genet 41, 5–6 (2009). https://doi.org/10.1038/ng0109-5

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  • DOI: https://doi.org/10.1038/ng0109-5

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