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Protein demethylation required for DNA methylation

Nature Genetics volume 41, pages 10–11 (2009)Cite this article

DNA methylation is an epigenetic mark directing stable, heritable gene silencing through development. A new study uncovers the importance of demethylation of the DNA methyltransferase-1 for maintenance of DNA methylation.

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Figure 1: Dynamics in protein methylation underlying DNA methylation.

References

  1. Forneris, F., Binda, C., Battaglioli, E. & Mattevi, A. Trends Biochem. Sci. 33, 181–189 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Cloos, P.A., Christensen, J., Agger, K. & Helin, K. Genes Dev. 22, 1115–1140 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wang, J. et al. Nat. Genet. 41, 125–129 (2009).

    Article  CAS  PubMed  Google Scholar 

  4. Wang, J. et al. Nature 446, 882–887 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Huang, J. & Berger, S.L. Curr. Opin. Genet. Dev. 18, 152–158 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Couture, J.F., Collazo, E., Hauk, G. & Trievel, R.C. Nat. Struct. Mol. Biol. 13, 140–146 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Lei, H. et al. Development 122, 3195–3205 (1996).

    CAS  PubMed  Google Scholar 

  8. Carlone, D.L. et al. Mol. Cell. Biol. 25, 4881–4891 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hirasawa, R. et al. Genes Dev. 22, 1607–1616 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kurihara, Y. et al. Dev. Biol. 313, 335–346 (2008).

    Article  CAS  PubMed  Google Scholar 

  11. Weber, M. et al. Nat. Genet. 39, 457–466 (2007).

    Article  CAS  PubMed  Google Scholar 

  12. Delaval, K. et al. EMBO J. 26, 720–729 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ooi, S.K. et al. Nature 448, 714–717 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zeng, F. & Schultz, R.M. Dev. Biol. 283, 40–57 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Godmann, M. et al. Biol. Reprod. 77, 754–764 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Antoine H.F.M. Peters and Hans-Rudolf Hotz are at the Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.,

    Hans-Rudolf Hotz & Antoine H F M Peters

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  1. Hans-Rudolf Hotz
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  2. Antoine H F M Peters
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Correspondence to Antoine H F M Peters.

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Hotz, HR., Peters, A. Protein demethylation required for DNA methylation. Nat Genet 41, 10–11 (2009). https://doi.org/10.1038/ng0109-10

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