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BRCA1—sowing the seeds crooked in the furrow

Nature Genetics volume 40, pages 8–9 (2008)Cite this article

Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers.

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Figure 1: A model for BRCA1-related breast carcinogenesis.

Katie Vicari

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  1. Departments of Oncology and Human Genetics, William D. Foulkes is in the Program in Cancer Genetics, McGill University, Montreal, Quebec H2W 1S6, Canada. william.foulkes@mcgill.ca,

    William D Foulkes

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  1. William D Foulkes
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Foulkes, W. BRCA1—sowing the seeds crooked in the furrow. Nat Genet 40, 8–9 (2008). https://doi.org/10.1038/ng0108-8

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